His physical exam was normal and the digital rectal examination revealed a slightly enlarged prostate. His past medical history was unremarkable. Laboratory data showed the following: Chest X-ray, bone scan, and abdominal CT scan were negative.
However, its clinical value has not been characterized. The aim of this study was to investigate the clinical value of the urine PCA3 test in the diagnosis of prostate cancer by pooling the published data.
A total of 46 clinical trials including 12, subjects were included in this meta-analysis. In conclusion, the urine PCA3 test has acceptable sensitivity and specificity for the diagnosis of prostate cancer and can be used as a non-invasive method for that purpose.
Prostate cancer is the most common cancer among men living in Western nations and now the most common malignancy with a prevalence near that of bladder cancer seen in urological clinics in China 1.
In the USA, prostate cancer is the most frequently diagnosed cancer and the second leading cause of cancer-related death in men, with an estimatednew cases and 29, deaths in 2. In clinical practice, serum prostate-specific antigen PSAdigital rectal examination DREtransrectal ultrasound, and biopsy are widely used for early detection.
Metastatic Prostate cancer: A case Study contributors: Kathryn cunningham, Md Division of Urology, The University of Texas Medical was the case with their original preparation. Forms of LHRH agonists used today are leuprolide, gos-erelin, triptorelin, and histrelin. patients with hormone-sensitive prostate . It’s based on principles of collaboration, unobstructed discovery, and, most importantly, scientific progression. As PhD students, we found it difficult to access the research we needed, so we decided to create a new Open Access publisher that levels the playing field for scientists across the world. "Prostate Cancer: Original Scientific Reports and Case Studies" ed. by Philippe E. Spiess InTeOpP | | ISBN: | pages | PDF | 12 MB This book encompasses sections pertaining to the topics of cancer biology, diagnostic markers, and therapeutic novelties.
InBussemakers et al. This non-invasive urine biomarker has been evaluated in many clinical studies, in several of which it was combined with other markers to improve the diagnostic accuracy in order to further rule out aggressive cancer at biopsy. Food and Drug Administration Medical Devices: We consider the current clinical evidence in investigating the diagnostic value of PCA3 in prostate cancer with both initial and repeat biopsy.
Methods This meta-analysis was performed in accordance with PRISMA 4 guidelines, which prefer reporting items from systematic reviews and meta-analyses. Search strategy and study selection A comprehensive, computerized literature search was performed in PubMed and Embase for work published through December using a combination of the following key words: Then, the reference sections of the identified publications were searched to identify additional potentially relevant articles.
Studies included in our meta-analysis had to meet the following criteria: Data extraction and quality assessment Data were extracted independently by 2 authors Y.
For each study, the following information was collected: When more than one article was published using the same population, we selected the most recent or most informative report. Disagreements between the two authors were resolved by consensus.
Forest plots were used, and methodological heterogeneity was assessed during selection. The threshold effect is a characteristic source of heterogeneity in the meta-analysis of diagnostic tests and arises when the included studies use different cut-off points to define a positive result of a diagnostic test.
Data were analyzed using the statistical software package Metadisc, version 1. The results were synthesized and represented graphically in a forest plot. If heterogeneity was found, the meta-analysis was performed using a random effects model. Results A total of 1, relevant references were obtained in our systematic search.
The results and study selection process are shown in Fig. In addition, one study by Hensen et al. Additionally, the study by Scattoni et al.treatment of hormone-related diseases such as breast and prostate cancer has become a promising endeavour for scientists.
Thus, there are many in vitro and in vivo studies investigating hormonal activities of traditionally used medicinal plants (Cordial et al., ; Parhizkar et al., ; Basu et al., ). Metastatic Prostate cancer: A case Study contributors: Kathryn cunningham, Md Division of Urology, The University of Texas Medical was the case with their original preparation.
Forms of LHRH agonists used today are leuprolide, gos-erelin, triptorelin, and histrelin.
patients with hormone-sensitive prostate . Yuanyuan Mi, Lijie Zhu and Ninghan Feng (November 21st ). Polymorphism Analysis of TRAIL Gene and Correlation TRAIL Expression in Prostate Cancer, Prostate Cancer Philippe E. Spiess, IntechOpen, DOI: / Available from: Yuanyuan Mi, Lijie Zhu and Ninghan Feng (November 21st "Prostate Cancer: Original Scientific Reports and Case Studies" ed.
by Philippe E. Spiess InTeOpP | | ISBN: | pages | PDF | 12 MB This book encompasses sections pertaining to the topics of cancer biology, diagnostic markers, and therapeutic novelties.
PROSTATE CANCER – ORIGINAL SCIENTIFIC REPORTS AND CASE STUDIES Edited by Philippe E. Spiess Prostate Cancer – Original Scientific Reports and Case Studies.
Chiech Huo and Liang-Cheng Su Preface In this. Prostate Cancer - Original Scientific Reports and Case Studies. Edited by: Philippe E. Spiess. ISBN , Published